HORMONES

Why should we be interested in hormones and hormonal substitution?

Because hormonal levels decline drastically with aging, this plays a predominant role in mental and emotional symptoms and in all illness.

Imbalance and lack leads to fatigue, sleep disturbance, sexual dysfunction, depression, impaired immune function, chronic illnesses, disease, "lack of thriving", degenerative state of decline, debility and earl death. Restoration is ideally achieved through Natural Hormonal Replacement Therapy - NHRT.

The decline in hormones with aging:

Pregnenolone 40% left with age of 70, growth hormone, testosterone, DHEA 50% decline from age 25 to 50, followed by a further 50% by the age of 75

Melatonin sharp, continual decline after age 50.

Melatonin secreted from pineal gland. Entrainment on circadian sleep-wake rhythm. Prevents neuronal damage, and nuclear and mitochondrial DNA damage. Boosts NK cells (which contain viral infections). Melatonin is found in animals, plants, fungi and bacteria. It is a powerful antioxydant with a particular role in the protection of nuclear and mitochondrial DNA. Against mitochondrial oxidative stress. When humans consume foods rich in melatonin such as banana, pineapple and orange the blood levels of melatonin significantly increase. Melatonin supplements do not affect REM sleep versus Benzodiazepine drugs.

Rare side effects:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; depression; fast heartbeat; hypothermia (fast breathing, shivering).

Progesterone, an anti-cancer hormone, keeps estrogen in check. A lack through aging or stress leads to estrogen dominance and all kinds of illness. Further, loss of hormonal balance, as occurs with aging, plays a predominant role in mental and emotional symptoms and in all illness. Restoration is ideally achieved through Natural Hormonal Replacement Therapy - NHRT.

24-hour saliva test from ZRT laboratory

This is a test kit that you can order directly from the lab yourself, or your doctor can provide you one which you then take home and complete. These home hormone saliva test kits have you collect a saliva sample in a small vial at 4 specific times of day (approximately 7 am, 11 am, 4pm and 11 pm). After you have collected your 4 specimens, you mail the kit to the lab for analysis. The test kit usually costs around $175, and includes the cost of analysis.

What are hormones?

Hormones transport information from nerve cells and glands to distant cells and organs. There they connect to a receptor like a key and a lock and thus jump start vital life functions. They coordinate all vital repair, recovery and regeneration, without them we simply degenerate.

Hormones are intimately involved in every body function. Every cell has a receptor site for a hormone to communicate with the cell to turn it on, off, vary its rate, and coordinate repair. The amount of hormones is controlled by two master – glands in the brain- the hypothalamus and the pituitary.

A hormone (from Greek ὁρμή, "impetus") gives a signal to cells, telling them what to do. Produced by glands or nerve cells it is transported by the circulatory system or nerve cells to target distant organs. Hormones are the interface between nerves/glands and body.

There are 4 types: Amine, peptide, protein, and steroid hormones. Steroid hormones got their name by a typical a four ring carbon structure. They derive from cholesterol.

Later we will have a closer look at steroid hormones since they are mainly made by the adrenals, and easily imbalanced or depleted.

Hormones are structured like a key

Hormones are very specific. They match a specific receptor like a key to a lock. Their specific shape is achieved by their 3 dimensional steric space structure.

Steric structure of Her2neu receptor protein of breast tissue

Steric effects arise from a fact that each atom within a molecule occupies a certain amount of space. If atoms are brought too close together, there is an associated cost in energy due to overlapping electron clouds (Pauli or Born repulsion), and this may affect the molecule's preferred shape (conformation) and reactivity.

Two kinds of hormones:

First: Neuro-Hormones released by nerve cells transmitting signals from one neuron to the next (neurotransmitters) such as Glutamate, GABA, Serotonin, Dopamine,

Second: Endocrine hormones which are released into the blood stream by endocrine glands and targeting cells far away such as Melatonin, Human Growth Hormone, FSH, LH, Thyroxin, Parathyroid Hormone, Insulin, Adrenal hormones (steroids), sex hormones testosterone, estrogen, and progesterone

Adrenalin and Noradrenalin are both, hormones and neurotransmitters.

Neuro-hormones (Neuro-transmitters)

Glutamate - Glutamic Acid the stimulator

The main activator of life functions is Glutamic acid. Glutamic acid is an important neurotransmitter that plays the principal role in neural activation. Glutamic acid is the most abundant excitatory neurotransmitter in the vertebrate nervous system.

Monosodium glutamate (MSG), the salt of Glutamic acid, is a flavor enhancer commonly added to Chinese food, canned vegetables, soups and processed meats. The Food and Drug Administration (FDA) has classified MSG as a food ingredient that's "generally recognized as safe," but I think differently. Because of very close metabolic interactivities of both substances, Glutamate is very problematic for many people:

Some side effects: Headache, flushing, sweating, facial pressure or tightness, numbness, tingling or burning in the face, neck and other areas, rapid, fluttering heartbeats (heart palpitations), chest pain, nausea, weakness, diarrhea immediately after food intake.

GABA: Gamma-Amino Butyric Acid

Gamma-Amino Butyric acid (GABA) controls glutamate by slowing it down and thus preventing over-stimulation. It is an amino acid which acts as a neurotransmitter in the central nervous system (CNS). It inhibits nerve transmission in the brain, calming nervous activity. As a supplement (250-750mg per day) it is sold and promoted for these effects as a natural tranquilizer. It is also touted as increasing Human Growth Hormone levels and is popular among body builders. Take GABA if you have a feeling of having had two cups of espresso. GABA has access to the hypothalamus which is not blocked by the brain blood barrier.

MS patients have shown to have low levels of GABA and glutamic acid.

GABA modulates many receptors and gives relief from stress, tension and depression, it is anti anxiety, very useful in treating epilepsy and several other neurological disorders. Effective in reducing the wrinkles and is also known for its anti-aging effect. It acts as a muscle relaxant and provides relief from stress and fatigue. Some of the health experts say that GABA plays a vital role in the breakdown of fats in the human body. Controlling high blood pressure and in some cases it is found very effective in reducing chronic arthritis and back pain. GABA being an amino acid plays a vital role in maintaining the production of certain hormones in the human body. It regulates many hormones of the body. Regulation of fat molecules.

Endocrine hormones:

They are released into the blood stream and travel through our vascular system to their destination.

Rare side effects:

Let’s have a look at the most important hormonal work force, the steroids, which are provided by the adrenal glands. In chronic disease, chronic stress, or chronic emotional upset they become depleted.

Steroids

Steroid hormones get their name by four cyclic carbon rings (steroid structure)

They run our metabolism (glucosteroids), water household (mineralosteroids), and reproduction (sex hormones). They are built by pregnenolone and DHEA.

Glucosteroids: cortisol, a catabolic hormone, increases blood sugar, suppresses the immune system, metabolizes fat, protein, and carbohydrates. It also decreases bone formation. It is the stress hormone. Cortisol should go down during sleep. In stress it goes up during sleep. GABA is one option to antidote the excitation.

A cortisol test may be used to help diagnose Cushing syndrome, a condition associated with excess cortisol, or to help diagnose adrenal insufficiency or Addison disease, or adrenal fatigue conditions associated with deficient cortisol. 24 hour urine Dexamethason test in order to rule out ACTH dependent increase of cortisol.

Mineralsteroids aldosterone influence on salt and water balances. The primary mineralocorticoid is aldosterone

Sex hormones estradiol and testosterone, progesterone. They are all more than sex hormones

Progesterone:

Despite it’s primary role to secure uterus functioning, hormonal imbalance almost always involves progesterone, because it serves as a pool for other hormones, and it is converting into many other hormones (stress hormones and sex hormones). That is why it’s equilibrium with estrogen can be impaired easily. Progesterone functions as a pool for stress hormones such as cortisol and sex hormones. It is an anti cancer hormone since it keeps estrogen in check. It could be easily depleted by chronic stress, emotional stress, chronic illness, inflammation, and xeno-estrogens such as heavy metal mercury, pesticides, and plastics. If Progesterone levels become low it cannot keep estrogen in check and estrogen dominance occurs with development of all kinds of disease, blood clots and cancer.

Progesterone is the most important controller

Progesterone is the parent or precursor of estrogen in the ovaries and the parent to cortisol and aldosterone in the adrenal glands. The adrenal glands manufacture progesterone from its precursor cholesterol. Any additional need of progesterone gives rise to cholesterol. Progesterone converts into testosterone, all androgens, and other adrenal hormones, making it extremely important for reasons far beyond its role as sex hormone, without it we could not cope with stress and our body fluid and kidney control would cease to function. It is the chain of hormonal conversion which makes life possible.

Steroid structure

Progesterone positives:

Protect the endometrium
Insure the optimal function of uterus
Anti-cancer hormone. It keeps estrogen in check
Prevent water retention
Help use fat for energy at the cellular level
Serve as a natural anti-depressant
Create a calming effect on the body
Help eliminate sleep disorders
Help keep insulin release in check and maintain even blood sugar levels
Prevent unmediated overgrowth of the endometrium/cancer
Prevent unmediated breast tissue overgrowth/cancer
Maintain sex drive
Maintain normal blood clotting parameters
Protect against fibrocystic breasts

Progesterone in men:

has a similar effect to the male hormone testosterone. Like testosterone, progesterone enhances your libido, improves your mood, helps keep your weight down and increases muscle mass, gives you more energy, stronger bones, stronger erections and a whole host of other health benefits. Progesterone also increases levels of testosterone in your body and enhances its effects. At the same time, it reduces estrogen and antagonizes estrogen effects.

As a man gets older testosterone is converted into di-hydrotestosterone (DHT), which some believe is the cause of benign prostatic hyperplasia (BPH) and cancer, but some do not.

estrogen levels also increase as a man gets older. estrogen is known to stimulate cell growth. It appears to be the increased estrogen level which is the problem and not the two testosterones. As progesterone is a powerful counter-balance for estrogen, progesterone for men is essential.

If in fact testosterone were the culprit, then men aged 22 would have the highest incidence of BPH and cancer, as testosterone levels are at their highest point in the early 20's, but of course they don't. From the early twenty's to the late twenty's testosterone makes it's greatest drop, thereafter it continues to decline, but at a slower rate.

BPH starts affecting a man in his fifties and interestingly estradiol levels start climbing from the age of fifty and are at their highest point in men in their late 60's, but during the same period progesterone levels are declining. Progesterone for men becomes that much more important with age.

5-alpha reductase inhibitors such as finasteride are usually given to prevent the conversion of testosterone to DHT, but research has found that progesterone is a natural inhibitor of 5-alpha reductase.

Progesterone also down regulates the action of estrogen if used in a sufficiently high dose. The endogenous estrogen made by humans is now being supplemented by synthetic estrogens found in the environment. They are now found in food, air, water, plastics, skin care products, no one can avoid them. Some authorities speculate this is the cause of the increase in problems such as hyperplasia or cancers of any hormonally sensitive tissues, such as the prostate, endometrium, cervix and breasts. So, despite often being, erroneously, thought of as a 'female' hormone progesterone for men is essential to preserve masculinity!

It's safety for men is without question. It's now given via IV transfusions for Traumatic Brain Injury. Over 70% of TBI victims are men.

Below are the reference ranges for estradiol, testosterone and progesterone for men...

Estradiol 0.5 - 2.2 pg/ml

Progesterone 15 - 100 pg/ml

Testosterone 44 - 148 pg/ml

Progesterone negatives are few and easily balanced by estrogen:

A sedating effect, if used in excess
Increased spotting and changes in bleeding patterns
Bloating if used in excess
Gastrointestinal discomfort
Acne, if used in excess
Hyperpigmentation of facial skin when exposed to sunlight

Many symptoms of hormonal imbalance are found only in modern society. Stress, processed foods, and other factors unique to modern society are the reasons many women do not get enough essential nutrients to create hormonal balance. It is almost always progesterone, not estrogen that is deficient. Virtually all the commonly known symptoms are those of estrogen dominance. When balance is restored by increasing natural progesterone levels, these symptoms typically disappear (see estrogen dominance)

Progesterone may be applied as bio-identical Progensa 20 cream on your forearms so that the body takes as much as it needs and avoiding break down in the liver when taking it orally

The negative effects of the growth induced by estrogen unopposed (acting alone), without the balancing effects of progesterone are:

Estrogen dominance

Progesterone keeps estrogen in check. If the estrogen/progesterone ratio is in favor of estrogen (estrogen dominance) disease occurs, especially tumors. Important are “xeno-estrogens” such as heavy metals (mercury), plastics, carcinogenic pesticides, herbicides, and insecticides, which all lead to estrogen dominance. High stress levels such as high cortisol levels also lead to estrogen dominance.

Increased accumulation of body fat, this is why livestock growers use this hormone
Increased water and salt retention
Interference with normal insulin release and blood sugar control
Increased risk of overgrowth of endometrium (lining of the uterus)
Increased risk of overgrowth of breast tissue, and could be a reason for breast cancer
Increased risk of depression
Increased risk of headaches
Increased risk of gallbladder disease
Increased incidence of blood clot formation
Prostate cancer

Soy bean-derived products and other phytoestrogens act as surrogate estrogens because of their content of genistein. Therefore they are keeping the xeno-estrogens in check.

Foods containing phytoestrogens include beans, soy products, peas, lentils, and whole grains and seeds, especially flaxseed, rye and millet. Lignans, isoflavones and coumestans have been the most carefully studied. Coumestans (phytoestrogens) a derivative of coumarin, are compound in the class of Flavonoids (polyphenols), found abundantly in split peas, pinto beans, lima beans, alfalfa and clover sprouts, etc. Isoflavone supplements, such as daidzein and genistein, are widely available.

Tamoxifen an estrogen receptor antagonist is used in breast cancer

Aromatase inhibitors inhibit conversion of androgens into estrogens in breast and prostate cancer.

Estrogen in women:

· Primary female sex hormone. Meaning “verve producer”. Development of breasts, pubic and armpit hair, endometrium, regulation of the menstrual cycle and the reproductive system. During the menstrual cycle, estrogen acts to produce an environment suitable for fertilization, implantation, and nutrition of the early embryo. It reduces circulating levels of FSH and LH.

· Most oral contraceptives contain a synthetic estrogen, along with a synthetic progestin which causes higher risk of blood clots.

The menstrual cycle occurs in three phases: follicular, ovulatory and luteal. The

first half of the cycle is known as the follicular phase and the second half of the

cycle is considered the luteal phase.

The follicular phase is controlled by estradiol.

Follicle-stimulating hormone (FSH) is secreted by the anterior pituitary gland. FSH secretion begins to rise in the last few days of the previous menstrual cycle, and is highest and most important during the first week of the follicular phase. The rise in FSH levels recruits five to seven tertiary-stage ovarian follicles (this stage follicle is also known as a Graafian follicle ) for entry into the menstrual cycle. These follicles, that have been growing for the better part of a year in a process known as folliculogenesis, compete with each other for dominance.

FSH induces the proliferation of granulosa cells in the developing follicles, and the expression of luteinizing hormone (LH) receptors on these granulosa cells. Under the influence of FSH, aromatase and p450 enzymes are activated, causing the granulosa cells to begin to secrete estrogen. This increased level of estrogen stimulates production of gonadotropin-releasing hormone (GnRH), which increases production of LH. Luteinizing hormone LH induces androgen synthesis by thecal cells, stimulates proliferation, differentiation, and secretion of follicular thecal cells and increases LH receptor expression on granulosa cells.^[3]

Throughout the entire follicular phase, rising estrogen levels in the blood stimulates growth of the endometrium and myometrium of the uterus.^[4] It also causes endometrial cells to produce receptors for progesterone,^[4] which helps prime the endometrium to respond to rising levels of progesterone during the late proliferative phase and throughout the luteal phase.

Estrogen surge

Many endocrinologists believe that the estrogen secretion of the dominant follicle has increased to a level that GnRH production is suppressed, which lowers the levels of LH and FSH. This slowdown in LH and FSH production leads to the atresia (death) of most of the recruited follicles, though the dominant follicle continues to mature.

The exact cause of polycystic ovary syndrome is unknown. Early diagnosis and treatment along with weight loss may reduce the risk of long-term complications, such as type 2 diabetes and heart disease.

Midway through the cycle between days 12 and 16 ovulation occurs, known as the ovulatory phase.

· Estrogen and other hormones are given to postmenopausal women in order to prevent symptoms of menopause such as hot flushes, vaginal dryness, dry eyes, urinary stress incontinence, chilly sensations, dizziness, fatigue, irritability, and sweating. Fractures of the spine, wrist, and hips decrease by 50–70%

Estriol for vaginal dryness

Estriol, an estrogen that has virtually been ignored by the mainstream medical community, is one of the three principal estrogens produced by the body. Estriol was originally thought to have little significance due to its weak estrogenic activity when compared with estrone and estradiol. Nonetheless, research has found that its weakness may very well be its strength.

Studies suggest that when the lower-potency estrogen, estriol, is administered topically, it does not increase the risk of hormone-dependent cancers of the breast or endometrium (uterine lining). However, having weaker estrogenic effects does not mean that estriol has none of the benefits that come with more potent estrogens. Studies suggest that estriol reduces symptoms of menopause, such as hot flashes and vaginal dryness, but with a better safety profile compared with more potent estrogens.This makes estriol a better choice for bioidentical hormone-replacement treatment regimes

Estrogen in men:

When estrogen levels are unbalanced, the risk of degenerative disease in aging men skyrockets. Excess estrogen contributes to the development of atherosclerosis. Men with even slightly elevated estrogen levels doubled their risk of stroke and had far higher incidences of coronary artery disease. Benign prostate enlargement or prostate cancer had higher blood estrogen levels (and often low free testosterone blood levels).

Insufficient estrogen, on the other hand, predisposes men to osteoporosis and bone fracture.

DHEA

It is the most abundant steroid hormone in the blood stream.It is vital for life. Mother of all hormones and derives from Pregnenolone. DHEA is also the parent hormone of estrogen and testosterone. Almost every cell has receptors. When the adrenals are chronically stressed, production of DHEA can be greatly reduced. It is a stress barometer. When stress goes up, DHEA goes down. It regulates the thyroid and pituitary, the thymus, and boosts Human Growth Hormone (HGH). Almost all the cells have receptors. Important regulator for thyroid, pituitary, thymus, HGH. It is an antioxidant. Building estrogenes and testosterone. Vitamin D enhances DHEA as does MSM and Pregnenolone. DHEA is supporting the cardiovascular system and seems to be very effective in trauma and septic inflammations.

Lack shows: poor memory, sensitive to noise, anxiety, decreased libido, decreased hair also axillary, pubic. DHEA-sulfate blood test

Testosterone:

Other than most hormones it does not log on the cellular membrane but penetrates directly toward the cell nucleus. It is a potent anti-aging hormone for the metabolism, stimulating red blood cell production, checking free radicals, protein synthesis and building muscle mass including the heart muscle. Marked reduced heart attacks both in women and men. It increases excitement and passion, and is an anti-depressant. Exercise will increase testosterone levels. Low levels cause loss of libido both in men and women, erectile dysfunction, and loss of strength and endurance. Testosterone levels decline by age, stress, heavy metals and xenoestrogens such as plasticides, and bisphenol A (BPA) a plastic compound found as lining in canned food and water bottles. Further by glucocorticoids such as cortisol.

Where could testosterone be dangerous?

In two scenarios in cases of prostate cancer: conversion of testosterone into DHT dihydro-testosterone, and testosterone conversion into estradiol by aromatase

1. Lower DHT Levels- Prostate cells grow in response to the hormone Dihydro-testosterone. Production of this hormone from testosterone can be blocked with prescription medications, such as Finasteride or Dutasteride, or with the over-the-counter supplement Saw Palmetto. Still, lowering DHT is the most effective means for lowering the overall number of prostate cancers and has been recommended by the American Urological Association and the American Society of Clinical Oncology.

Testosterone is also converted into the estrogen estradiol by an enzyme aromatase. Thus it could be again an estrogen which would be producing cancer

2. Eat Your Cruciferous Veggies-like broccoli. Men who ate one of the cruciferous vegetables, which also includes cauliflower and kale, more than once a week were 40% less likely to develop prostate cancer. This may be related to a chemical, indole-3-carbinol, which has effects on hormone metabolism. This same chemical has been linked to lower risk of breast cancer.

3. Eat Tomato Products – reduced risk of prostate cancer may be related to the anti-oxidant lycopene although this is still uncertain. Cooking the processed tomatoes and eating them with oil or fat may also increase the absorption of lycopene and related compounds. Therefore, pizza may be an excellent anti-cancer food.

I test the free testosterone which represents the amount available for the tissues.

Glucosteroid:

Cortisol is most important in the glucose metabolism. It has katabolic properties. That is it slows and blocks all kinds of metabolic processes including the immune system. It turns immune activities down. Therefore it is used in medicine to control overactive allergic and inflammatory conditions including allergies, sepsis and leukemia.

· The following are indications of an excessive cortisol level:

· accelerated skin aging and deterioration;

· damaged structure and function of mid-brain regions involved in memory; vision, hearing, motor control, sleep/wake, arousal, alertness, and temperature regulation.

· impaired wound healing, poor skin quality and excessive scar tissue;

· excess fluid retention and puffy, flabby skin.

· poor quality of sleep

Cholesterol, Vitamin D, and bile: are also steroids

Thyroid hormones

primary regulators of metabolism triiodothyronine (T₃) and its prohormone, thyroxine (T₄). They are tyrosine-based hormones produced by the thyroid gland that are primarily responsible for regulation of metabolism.

A loss of hormonal balance, as occurs with aging, plays a predominant role in mental and emotional symptoms and in all illness. Restoration is ideally achieved through natural hormonal replacement therapy.

Imagine your health status in 10 years from now if you already today worry about persistent complaints and decline of energy. Many of us talk about lacking energy among other symptoms. Aging reduces the amount of hormones dramatically which leads eventually to collapsing of the entire organ network.

Here is where energy medicine comes in. Energy medicine identifies and eliminates mental and physical toxic waste, and this jump starts your cell metabolism.

Part of that program includes hormonal therapy. Natural Hormonal Replacement Therapy (NHRT) with bioidentical hormones has become a mile stone in rejuvenating and anti-aging efforts.

Pregnenolone

It is the precursor (building-block) for all other steroid hormones. It is converted directly into DHEA and/or progesterone.

Where is Pregnenolone formed?

Pregnenolone is the precursor of many steroid-hormones. It is mainly produced in the adrenals albeit it is also synthesized in the brain, liver, skin, testicles, ovaries, and retina.

Live cycle of Pregnenolone

In youth we find highest amounts of Pregnenolone. Decrease starts at the age of 25 with steady decrease along with the aging.
At 75 years the body produces about 60% less Pregnenolone versus age 30. This is why Pregnenolone is an important parameter for aging.

Because it is the “grand mother” substance in the functional chain of hormones it is responsible for the steady overall decrease of power of our body when we grow older, because over the life time span of a person this hormone is depleted by the aging process. That is why sufficient amounts of Pregnenolone are a guard against complaints going along with aging.

General impact of Pregnenolone on our organism

Pregnenolone strengthens the protecting myeline sheath of our nerve cells, which are constantly attacked by toxic environmental substances.
It improves the over all feeling, mental functions, improves vigilance, stimulating clear and swift thought processing, elevates concentration and cognitive functions, alertness, supports creativity, keeps brain functions on optimal levels, triggers desire to learn and to try out new things. It improves psychic energy levels as well as speech and visual capacity. Degenerative effects of aging are slowed and the over all aging of memory is reduced.

Stress increases cortisol levels, inhibiting and compromising the immune system, triggers calcium loss and possible Osteoporosis.

Pregnenolone in combination with Melatonin has proven to be a potent player against cortisol in order to manage stress.

How does lack of Pregnelonone affect our body?

Lack of Pregnenolone provokes lack of energy, weak memory, causes visual and acoustic impairment, arthritis, heart disease, memory loss, mood fluctuations such as depression, and reduces libido.

Pregnenolone and brain function

Pregnenolone levels are multi-fold higher in the human brain than in the blood. This highlights the importance of the hormone for healthy brain functioning.
As a neuro-steroid, Pregnenolone is formed in brain cells. However, its production decreases rapidly with aging.
Pregnenolone belongs to the most effective known steroids responsible for both brain and memory power. It improves the memory and learning phase. Pregnenolone modulates diverse signal transfers from neuron to neuron and thus largely influences learning and memory processes.

Pregnenolone interferes with multiple brain receptors such as GABA (Gamma-amino-butyric acid) and NMDA (N-Methyl-D-Aspartate), NMDA receptors play an important role for signal transfer for both learning and memory.
Aging goes along with loss of NMDA-Receptors (N-methyl-D-aspartate) and therefore is in part responsible for loss of learning and memory. Alcohol, by the way, is also blocking NMDA-receptors, which is responsible for memory loss after alcohol consume.

Pregnenolone also triggers acetylcholine, which also impacts memory.
New studies show that minute dosages of Pregnenolone could have astounding memory improvement. Among all steroid hormones Pregnenolone seems to render the best memory improvement and could be administered in 100 times smaller dosages than other memory boosting substances (post learning memory function). According to American research Pregnenolone has proven to enhance memory even after brain injury.

Pregnenolone reduces psychic and physical fatigue. More energy is gained on the psychic level. Function of sensory organs such as ears and eyes can be improved. Colors appear brighter and clearer. Contours and objects become sharp edged, so that they can be visualized better.

Diseases treatable with Pregnenolone

Pregnenolone has shown positive results both in psychic and organic disease.
It has been substantially helpful in depression and manic depression disorder. Further in depressive moods (dysthymia) with signs of helpnessness, tiredness, low self steem, sleeping and eating disorders, lacking motivation, and chronic-fatigue-syndroms (CFS)

It is an option in cases of Addison, Parkinson, Alzheimer, multiple sclerosis, nerve injury by accidents, burns, and electrical shock.
Pregnenolone slows down skin aging, smoothing the skin, builds up muscles, and boosts the immune system. In diabetes it helps renewing the Beta cells and can be suggested for people beyond 40 years of age.

Pregnenolone has anti-inflammatory qualities and is useful against rheumatic diseases of joints (arthritis), of the spinal column, and spondylitis ancylotica. Versus cortisol it has no side effects.
It is also helpful against heart disease, high cholesterol, visual- and hearing impairment, pre-menstrual syndrome, benign prostate hyperplasia, or autoimmune disease such as Lupus erythematodes or scleroderma.
The older and unhealthier the patient, the more the benefit of Pregnenolone can be felt .

Which hormones are modulated by Pregnenolone?

Foremost Pregnenolone is the precursor of the adrenal hormone Dehydroepiandrosteron (DHEA). Therefore it may be combined with DHEA without hesitation.
Whereas DHEA is considered the „mother“ of all hormones, Pregnenolone may be called „grand mother” of all steroid hormones. In the human body over 150 steroid hormones derive from Pregnenolone

Does Pregnenolone have negative impact on other hormones?

In the body Pregnenolone is circulating as water soluble Pregnenolone-sulfate.
In progressed age Pregnenolone may be administered in tandem with other hormones such as DHEA without hesitation or fear, because there is only minute transformation of Pregnenolone into DHEA or into other steroid hormones. With progressing age, enzymes needed for that transformation are excreted in minute amounts only. That shows that there is hardly any transformation. Consequently there will not be overdosing.

Does Pregnenolone have positive interaction with other hormones?

Pregnenolone together with DHEA enhances health all over and is also applied in combination with Melatonin as an anti-aging remedy.

Specifically in traditional estrogen hormonal replacement therapies, estrogen dosage could be minimized by Pregnenolone in combination with DHEA and Melatonin. That is how adverse estrogen side effects need not to be feared. Bone and heart diseases as well as typical symptoms of menopause such as hot flashes and sleeping disorders could be treated even with lowest estrogen substitution.

Ways of Pregnenolone application

Pregnenolone must be compounded as capsules by a pharmacy according to medical prescription. Pregnenolone cannot be administered as herbal precursors because our body cannot synthesize them into Pregnenolone.

What dosage is needed?

10 mg for light memory complaints up to 100mg per day if necessary. Adults over 40 years of age take an average of 10mg per day. Over 50 years of age 25 mg, and over 60 years 50 mg Pregnenolone.
This dosage secures ideal hormonal Pregnenolone levels as we have it at the age of 20-30.

Aging slows down. It should be taken in the morning before breakfast.

Which are the side effects of Pregnenolone?

Unwanted side effects are not known. As a caution it should not be taken during pregnancy and lactation.

Pregnenolone against anti-aging ?

It is evident that Pregnenolone renders marked improvement of life quality, over all health, and well being. Thus it can postpone aging processes.
Since Pregnenolone is transformed into Progesteron, DHEA, Testosterone, and estrogen it enhances longevity by slowing the aging process and plays a remarkable role for positive life quality all over.

Energizing, Anti-stress Benefits

Pro-memory Effects

Mood elevation

Anti-arthritis Effects

Pregnenolones Cortisol-neutralizing Power of excessive cortisol

Safety

Fortunately, pregnenolone is amazingly safer than other steroids. Pregnenolone researchers working with both human and animal subjects since the 1940s have consistently commented on pregnenolones virtual absence of toxicity. For example, the classic review article on pregnenolone by Henderson and colleagues in 1950 states: 'It [pregnenolone] has an extremely low order of toxicity; [it] has not shown any adverse effects on endocrine [hormone] physiology ....'

Pregnenolone has been given orally to humans at doses as high as 500 mg/day for as long as 30 weeks without evidence of adverse effects. Mice given 5 grams (1/6 ounce) per kilogram (2.2 pounds) of body weight suffered no ill effects. This would be equivalent to a 154 pound (70 kilogram) human ingesting 350 grams (approximately 3/4 pound) per day! In a long-term study, mice

HGH production in pituitary. Insulin like growth factor. Antagonist to insulin. During sleep released. Cell repair. Zinc is important for production. Sugar is lowering HGH.

Danger of HGH?

Supplementation of HGH may induce colo-rectal cancer and other de-novo cancers.

Insulin lowers blood sugar by opening the cellular doors for sugar. Lowers estrogen. High Insulin levels lower HGH. Insulin has profound impact on aging.

Further neurotransmitters

Serotonin

90% found in the gastro-intestinal tract. Responsible for digestion, well being, happiness, appetite, sleep, mood. Serotonin and Dopamin are antagonists. This suggests that the dopaminic substantia nigra in the brain may be adversely influenced by food intake and the intestine-related serotonin.

Dopamine

reward motivated behavior. Most types of reward increase the level of dopamine in the brain, and a variety of addictive drugs increase dopamine neuronal activity. Other brain dopamine systems are involved in motor control. Parkinson`s disease, a degenerative condition causing tremor and motor impairment, has been related to the loss of dopamine-secreting neurons in the midbrain area called the substantia nigra. There is evidence that schizophrenia involves highly altered levels of dopamine activity, and the antipsychotic drugs that are frequently used to treat it have a primary effect of attenuating dopamine activity. Attention deficit hyperactivity disorder (ADHD) and restless legs syndrome (RLS) are also believed to be associated with decreased dopamine activity. The connection between the substantia nigra and the corpus striatum is critical to produce smooth, purposeful movement. Loss of dopamine in this circuit results in abnormal nerve-firing patterns within the brain that cause impaired movement. People with Parkinson's also have loss of the nerve endings that produce the neurotransmitter Norepinephrine, which is closely related to dopamine

Adrenalin

kick starts metabolism. Flight or fight reaction. Bronchodilation. Cardiac arrest.

Noradrenalin

vigilance, paying attention to as opposed to Dopamine for cognitive alertness. Alpha 1 blockers relax certain muscles and help small blood vessels remain open. They work by keeping the hormone norepinephrine (noradrenaline) from tightening the muscles in the walls of smaller arteries and veins. Blocking that effect causes the vessels to remain open and relaxed. This improves blood flow and lowers blood pressure.

Because alpha blockers also relax other muscles throughout the body, these medications can help improve urine flow in older men with prostate problems.

α₂-blockers have found medical uses in treating depression; the tetracyclic antidepressants mianserin and mirtazepin are α₂-blockers, although their efficacy as antidepressants may come from their activity at other receptor sites.

Mechanistically, α₂-blockers significantly increase adrenergic, dopaminergic and serotonergic neurotransmitters, and induce insulin secretion and decreases blood sugar levels.

Acetylcholine

Principal neurotransmitter of the autonomic nervous system and peripheral motor system.

It is also a transmitter of the central nervous system (CNS)

Pharmacy compounding

is the art and science of preparing personalized medications for patients. Compounded medications are made based on a practitioners prescription in which individual ingredients are mixed together in the exact strength and dosage form required by the patient. This method allows the compounding pharmacist to work with the patient and the prescriber to customize a medication to meet the patient’s specific needs.